CTICasesTransfusion-Related Hepatosplenic and Lymph Node Hemosiderosis
[...]. Transfusion-Related Hepatosplenic and Lymph Node Hemosiderosis. CTICases. Published November 30, 2016. https://str-case-explorer.pages.dev/c/28dwh
Imaging findings
Non-contrast chest CT of a patient with myelodysplastic syndrome and a history of chronic blood transfusions demonstrates marked hyperattenuation of both the liver and the lymph nodes surrounding the porta hepatis. This highly dense appearance is caused by extensive iron deposition (hemosiderosis) within the reticuloendothelial cells.
Key takeaways
Chronic transfusion therapy can lead to systemic iron overload, resulting in striking hyperattenuation of the liver, spleen, and regional lymph nodes on non-contrast CT. This distribution is characteristic of reticuloendothelial hemosiderosis and should not be mistaken for surgical clips or calcified granulomatous disease.
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