CTICasesBrown Tumors in Primary Hyperparathyroidism
[...]. Brown Tumors in Primary Hyperparathyroidism. CTICases. Published February 7, 2020. https://str-case-explorer.pages.dev/c/w56fz
Imaging findings
CT chest and skeletal survey show multiple expansile, lytic bone lesions in the humeral heads, scapula, and ribs, associated with a pathological humerus fracture and medullary nephrocalcinosis in the kidneys.
Key takeaways
Brown tumors are non-neoplastic, expansile lytic bone lesions caused by osteoclast hyperfunction in severe hyperparathyroidism (typically primary, from an adenoma). They closely mimic multiple myeloma or osteolytic metastases, but lack extraosseous soft-tissue components and are accompanied by nephrocalcinosis.
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