CTICasesCytokine Release Syndrome and Pulmonary Toxicity post CAR-T Cell Therapy
[...]. Cytokine Release Syndrome and Pulmonary Toxicity post CAR-T Cell Therapy. CTICases. Published May 13, 2021. https://str-case-explorer.pages.dev/c/dysuw
Imaging findings
Chest radiograph shows advanced right medial lung cancer and a lytic lesion in the scapula. Post CAR-T infusion, the radiograph and chest CT demonstrate diffuse lung disease with prominent septal lines and crazy paving, indicating capillary leak and alveolar edema secondary to cytokine release syndrome.
Key takeaways
Chimeric antigen receptor (CAR) T-cell therapy, while widely used for hematologic malignancies, is being investigated for solid tumors. ROR1-targeted CAR-T therapy can lead to pulmonary toxicity and cytokine release syndrome (CRS), manifesting as diffuse alveolar damage, capillary leak, and severe crazy-paving pattern on CT.
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